Figure 1

Morphologic factors included in the MMR index. A) Expanding growth pattern (x5), B) Tumor-infiltrating lymphocytes (x40), C) Mucinous differentiation (x10) and D) Dirty necrosis (x20). E) Receiver operating characteristic curve demonstrating sensitivity and specificity for an increasing number of factors in the index. Area under the curve 0.94. The suggested cut-off point (≥4 factors) is marked by a red dot.