Efficient and reproducible identification of mismatch repair deficient colon cancer: validation of the MMR index and comparison with other predictive models

Table 3 Performance of the different prediction models for MMR (n = 200)

Model	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC
MMR index	97.5	68.8	44.3	99.1	0.83
4 features present
PREDICT	95.0	66.3	41.3	98.2	0.81
Score ≥2.5
Simplified PREDICT	95.0	65.0	40.4	98.1	0.80
2 features present
MsPath	100.0	40.6	29.6	100.0	0.70
Score ≥1
MSI probability score	100.0	45.6	31.5	100.0	0.73
Score ≥1	97.5	56.3	35.8	98.9	0.77
Score ≥1.5
RERtest6	60.0	99.4	96.0	90.8	0.80
Score <0.8

Abbreviations: AUC area under curve, MMR mismatch repair, MSI microsatellite instability, NPV negative predictive value, PPV positive predictive value.

ISSN: 1472-6890