Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer

BMC Clinical Pathology

Table 1 Patient and tumor characteristics and results of molecular and immunohistochemical analyses

Variable	Categorization	n analyzable	%
Total n = 174
*Clinico-pathologic data:*
Age at diagnosis (median, range)		69,5 years (32–92)
	<70 years	87	50.0
	≥70 years	87	50.0
Sex
	Female	43	24.7
	Male	131	75.3
Tumor stage (WHO 1973^a)
	pTa	90	51.7
	pT1	68	39.1
	pT2	13	7.5
	pT3	2	1.1
	pT4	1	0.6
Histologic grade (WHO 1973^a)
	G1	44	25.3
	G2	87	50.0
	G3	43	24.7
Histologic grade (WHO 2004^b)
	Low grade	101	58.0
	High grade	73	42.0
Adjacent carcinoma in situ
	No	158	90.8
	Yes	16	9.2
Multiplicity
	Solitary	124	71.3
	Multifocal	50	28.7
Growth pattern
	Papillary	159	91.4
	Solid	15	8.6
*Immunohistochemistry (IHC):*
HDAC-1
	Low expression	104	59.8
	High expression	70	40.2
HDAC-2
	Low expression	101	58.0
	High expression	73	42.0
HDAC-3
	Low expression	71	40.8
	High expression	103	59.2

ISSN: 1472-6890