Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer

BMC Clinical Pathology

Table 2 Associations of the HDAC-1, -2 and 3 and Ki-67 with pathologic characteristics (n = 174)

Variable	Categorization	HDAC-1 expression			HDAC-2 expression			HDAC-3 expression			Ki-67 expression
		Low	High	p	Low	High	p	Low	High	p	Low	High	p
Tumor stage (WHO 1973)^a
	pTa	59	31	0.162	55	35	0.811	37	53	0.257	71	19	<0.001
	pT1	37	31		37	31		30	38		35	33
	pT2	5	8		7	6		2	11		2	11
	pT3	2	0		1	1		1	1		0	2
	pT4	1	0		1	0		1	0		0	1
Histologic grade (WHO 1973)^a
	G1	29	15	0.022	32	12	0.026	20	24	0.425	39	5	<0.001
	G2	57	30		50	37		37	50		61	26
	G3	18	25		19	24		14	29		8	35
Histologic grade (WHO 2004)^b
	Low grade	71	30	0.001	68	33	0.005	49	52	0.019	87	14	<0.001
	High grade	33	40		33	40		22	51		21	52
Adjacent carcinoma in situ^b
	No	96	62	0.432	96	62	0.032	65	93	1.00	105	53	<0.001
	Yes	8	8		5	11		6	10		3	13
Multiplicity^b
	Solitary	79	45	0.124	77	47	0.093	49	75	0.587	86	38	0.003
	Multifocal	25	25		24	26		22	28		22	28
Growth pattern^b
	Papillary	97	62	0.278	94	65	0.416	65	94	1.00	107	52	<0.001
	Solid	7	8		7	8		6	9		1	14

ISSN: 1472-6890